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Biostimulators

Collagen biostimulators are injectables that stimulate new collagen production over time.

Bar chart from a 2024 prospective study of 30 Asian participants who had three intradermal polynucleotide (PN HPT) sessions: at 6 months, 43 percent rated their skin very much improved and 33 percent much improved.

Polynucleotide skin boosters (Rejuran): 2026 evidence

What polynucleotide injectables do, what the systematic review data shows, how they compare with HA boosters, adverse events, and patient selection.

May 27, 2026 · 6 min · Medically reviewed

Bar chart from a 2024 multicenter retrospective study of 274 treatment sessions in 167 patients: the most common adverse events were bruising in 6.57 percent of face and 7.69 percent of body treatments and mild pain in 3.07 percent of face treatments; no event needed further intervention.

Sculptra (poly-L-lactic acid) biostimulator: 2026 evidence

Mechanism of collagen induction, expected timeline, reconstitution evidence, recognized complications, and patient selection for PLLA.

May 26, 2026 · 6 min · Medically reviewed