Dermatology Xagena

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Treatment of androgenetic alopecia: efficacy of Rosemary oil vs Minoxidil 2%

Rosmarinus officinalis L. is a medicinal plant with diverse activities including enhancement microcapillary perfusion.

A study aimed to investigate the clinical efficacy of rosemary oil in the treatment of androgenetic alopecia and compare its effects with Minoxidil 2%.

Patients with androgenetic alopecia were randomly assigned to rosemary oil ( n=50 ) or Minoxidil 2% ( n=50 ) for a period of 6 months.

After a baseline visit, patients returned to the clinic for efficacy and safety evaluations every 3 months. A standardized professional microphotographic assessment of each volunteer was taken at the initial interview and after 3 and 6 months of the trial.

No significant change was observed in the mean hair count at the 3-month endpoint, neither in the rosemary nor in the Minoxidil group ( P more than 0.05 ).

In contrast, both groups experienced a significant increase in hair count at the 6-month endpoint compared with the baseline and 3-month endpoint ( P less than 0.05 ).

No significant difference was found between the study groups regarding hair count either at month 3 or month 6 ( P more than 0.05 ).

The frequencies of dry hair, greasy hair, and dandruff were not found to be significantly different from baseline at either month 3 or month 6 trial in the groups ( P more than 0.05 ).

The frequency of scalp itching at the 3- and 6-month trial points was significantly higher compared with baseline in both groups ( P Scalp itching, however, was more frequent in the Minoxidil group at both assessed endpoints ( P less than 0.05 ).

The findings of the present trial provided evidence with respect to the efficacy of rosemary oil in the treatment of androgenetic alopecia. ( Xagena )

Panahi Y et al, Skinmed 2015;13:15-21