Dermatology Xagena

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Stratifin gene defect leading to abnormal skin development and cancer identified

Researchers at Jefferson Medical College and at the Wadsworth Center in New York have identified a gene defect in mice resulting in a range of abnormalities, from cyclical hair loss and skin cancer to severe problems in normal skin development.

The work may lead to improved treatments for skin injuries, including burns, and might have implications for diseases such as eczema and psoriasis, as well as certain cancers.

Linda Siracusa, at Thomas Jefferson University in Philadelphia and at Jefferson's Kimmel Cancer Center and Bruce Herron, at the Wadsworth Center of the New York State Department of Health and at the State University of New York at Albany, wanted to identify the nature of an inherited genetic mutation in mice called repeated epilation ( Er ), and pinpoint the gene itself.

Mice carrying one copy of the mutation have cyclical hair loss, and develop skin cancer late in life. Mice carrying two copies have severe defects in skin development related to keratinocyte differentiation. At birth, they lack external openings – the nose and mouth are covered by skin, for example – and live only a brief time.

Previous studies had pinned the gene's location to mouse chromosome 4.

The research team described in the journal Nature Genetics how it subsequently narrowed the region on chromosome 4 to about 800 megabases, eventually uncovering a mutation in a gene, Stratifin.

Stratifin is highly expressed in the epidermis and plays a role in preventing human cancers.
The researchers identified an "insertion" mutation in the gene that resulted in a damaged Stratifin protein.

" We looked at a number of inbred strains and only saw a mutation in the Stratifin gene in mice with the repeated epilation features," Herron sais. When the repeated epilation mutation was "rescued" by providing a molecular carrier containing normal genetic regions of chromosome 4, the mice had normal hair development.

" We were interested in genes affecting susceptibility to the development of skin cancer, and the repeated epilation mice provided a good model," Siracusa said. The initial goal of the work was to find out what gene was responsible for the repeated epilation mutation.

" We think the mutation is potentially another player in what could be a relatively novel pathway affecting the development of hair and skin," Herron said. The Stratifin gene is present in humans, and comparable genetic defects are under investigation.

Siracusa and Herron's laboratories are continuing to collaborate to understand the mechanisms behind the gene defect's effects on skin development, hair growth and tumor development.

The researchers note that Stratifin is turned off in many cancers, suggesting it may protect cells from becoming cancerous. The Stratifin gene could help lead to a better understanding of the susceptibility to and development of epithelial cancers such as those of the breast, prostate, skin, lung, ovary and colon, and could predict a person's response to cancer therapy. Further studies may also lead to applications for hair loss treatment.

Source: Thomas Jefferson University, 2005